文献类型: 外文期刊
作者: Luo, Yabiao 1 ; Xu, Qiao 1 ; Xue, Mingming 1 ; Wang, Yubei 1 ; Yang, Xiaoyang 1 ; Chan, Shuheng 1 ; Tang, Qiguo 1 ; Wang, Feng 3 ; Sun, Ruiping 3 ; Chao, Zhe 3 ; Fang, Meiying 1 ;
作者机构: 1.China Agr Univ, Coll Anim Sci & Technol, MOA Lab Anim Genet & Breeding, Natl Engn Lab Anim Breeding,Dept Anim Genet & Bree, Beijing 100193, Peoples R China
2.Nanchang Normal Univ, Inst Biol Technol, Jiang Xi Prov Key Lab Genet Improvement Indigenous, Nanchang 330029, Peoples R China
3.Hainan Acad Agr Sci, Inst Anim Sci & Vet Med, Haikou 571100, Peoples R China
4.China Agr Univ, Sanya Inst, Sanya 572025, Peoples R China
关键词: HHEX; body length; expression pattern; gene polymorphism; promoter activity
期刊名称:GENES ( 影响因子:3.5; 五年影响因子:3.9 )
ISSN:
年卷期: 2023 年 14 卷 2 期
页码:
收录情况: SCI
摘要: The screening of important candidate genes and the identification of genetic markers are important for molecular selection in the pig industry. The hematopoietically expressed homeobox (HHEX) gene plays an important role in embryonic development and organogenesis; however, the genetic variation and expression pattern of the porcine HHEX gene remains to be clarified. In this study, semiquantitative RT-PCR and immunohistochemistry results showed the specific expression of the HHEX gene in porcine cartilage tissues. A novel haplotype consisting of two SNPs rs80901185 (T > C) and rs80934526 (A > G) was detected in the promoter region of the HHEX gene. The expression of the HHEX gene was significantly higher in Yorkshire pigs (TA haplotype) than in Wuzhishan pigs (CG haplotype), and a population analysis showed that this haplotype was significantly associated with body length. An analysis subsequently revealed that the -586 to -1 bp region of the HHEX gene promoter showed the highest activity. Furthermore, we found that the activity of the TA haplotype was significantly higher than that of the CG haplotype by changing the potential binding of transcription factors YY1 and HDAC2. In summary, we conclude that the porcine HHEX gene may contribute to the breeding of pigs for body length traits.
- 相关文献
作者其他论文 更多>>
-
Effects of dietary supplementation with dandelion tannins or soybean isoflavones on growth performance, antioxidant function, intestinal morphology, and microbiota composition in Wenchang chickens
作者:Li, Xiang;Sun, Ruiping;Ou, Yangkun;Qi, Qi;Xie, Yali;Wei, Limin;Li, Xiang;Gong, Yuanfang;Liu, Quanwei;Zhao, Guiping;Wei, Limin;Wang, Xiuping;Hu, Chenjun;Jiang, Shouqun
关键词:growth performance; biochemical blood indexes; antioxidant function; intestinal health; dandelion tannin; soybean isoflavones; Wenchang chicken
-
Integrated Analysis of Transcriptome Expression Profiles Reveals miRNA-326-NKX3.2-Regulated Porcine Chondrocyte Differentiation
作者:Xu, Qiao;Luo, Yabiao;Liu, Ximing;Tang, Qiguo;Wang, Kejun;Fang, Meiying;Chao, Zhe;Tan, Shuyi;Zhang, Jibin;Xu, Qiao
关键词:pig; vertebral column; RNA-seq; non-coding RNAs; NKX3; 2
-
Dietary Supplementation with Putrescine Improves Growth Performance and Meat Quality of Wenchang Chickens
作者:Qi, Qi;Zhao, Guiping;Wei, Limin;Qi, Qi;Sun, Ruiping;Liu, Quanwei;Ouyang, Kun;Xie, Yali;Li, Xiang;Wu, Wei;Liu, Yuhang;Wei, Limin;Hu, Chengjun;Zhang, Haojie
关键词:amino acid; fatty acid; growth performance; putrescine; Wenchang chickens
-
Regulatory functional role of NLRP3 inflammasome during Mycoplasma hyopneumoniae infection in swine
作者:Zhang, Yan;Cao, Zongxi;Chao, Zhe;Liu, Hailong;Zhang, Yan;Cao, Zongxi;Chao, Zhe;Liu, Hailong;Liu, Bo;Xie, Jinwen;Tian, Fengrong;Li, Shuguang;Wang, Wenxiu;Liu, Bo;Said, Abdelrahman;Said, Abdelrahman;Li, Feng;Wang, Wenxiu;Li, Xin
关键词:Mycoplasma hyopneumoniae; NLR family pyrin domain containing 3 (NLRP3) inflammasome; pro-inflammatory cytokines; Swine
-
Plant miR167e-5p promotes 3T3-L1 adipocyte adipogenesis by targeting beta-catenin
作者:Chen, Ting;Xi, Qianyun;Sun, Jiajie;Zhang, Yongliang;Ma, Fei;Peng, Yongjia;Zhang, Jin;Li, Meng;Sun, Ruiping
关键词:Exogenous; miRNA; Cross-kingdom; Adipogenesis
-
The grain yield regulator NOG1 plays a dual role in latitudinal adaptation and cold tolerance during rice domestication
作者:Huo, Xing;Xiao, Junyi;Peng, Xin;Liu, Dilin;Liu, Wuge;Liao, Yilong;Li, Jinhua;Zhu, Manshan;Fu, Chongyun;Zeng, Xueqin;Ma, Xiaozhi;Kong, Le;Wang, Feng;Xiao, Junyi;Lin, Yanhui
关键词:NOG1; cold stress; domestication; differentially expressed genes; RNA-seq
-
A Combined Differential Proteome and Transcriptome Profiling of Fast- and Slow-Twitch Skeletal Muscle in Pigs
作者:Wei, Wei;Zha, Chengwan;Jiang, Aiwen;Hou, Liming;Liu, Honglin;Huang, Ruihua;Wu, Wangjun;Chao, Zhe
关键词:pig; proteome; transcriptome; muscle fiber; meat quality