您好，欢迎访问湖北省农业科学院 机构知识库！
湖北省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Vitexin and isovitexin delayed ageing and enhanced stress-resistance through the activation of the SKN-1/Nrf2 signaling pathway

文献类型： 外文期刊

作者： Tao, Mingfang 1 ; Li, Rong 1 ; Xu, Tingting 1 ; Zhang, Zhuo 1 ; Zheng, Dan 2 ; Xia, Zhenzhen 2 ; Wu, Ting 1 ; Pan, Siyi 1 ; Xu, Xiaoyun 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Food Sci & Technol, Key Lab Environm Correlat Dietol, Minist Educ, Wuhan 430070, Peoples R China

2.Hubei Acad Agr Sci, Inst Agr Qual Stand & Detect Technol, Hubei Key Lab Nutr Qual & Safety Agroprod, Wuhan, Peoples R China

3.Jingchu Univ Technol, Res Inst Agr Biotechnol, Jingmen, Peoples R China

关键词： Ageing; Caenorhabditis elegans; stress resistance; SKN-1/Nrf2

期刊名称：INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION （ 影响因子：3.9； 五年影响因子：4.1 ）

ISSN： 0963-7486

年卷期： 2023 年 74 卷 6 期

页码：

收录情况： SCI

摘要： Vitexin and isovitexin, as potential SKN-1/Nrf2 (SKN-1 is a homologous protein of mammalian Nrf2) activators, extended lifespan and promoted healthspan in Caenorhabditis elegans. This study aims to elucidate the role of SKN-1/Nrf2 in vitexin and isovitexin-induced anti-aging and stress-resistance. Vitexin and isovitexin upregulated antioxidant gene and protein expressions, reduced ROS accumulation, and increased SKN-1 accumulation in the nucleus. They prolonged lifespan and clear ROS during stressful conditions in a skn-1-dependent manner. skn-1 was also found to be necessary for these compounds-induced longevity under normal conditions. They were also witnessed to retard cellular senescence and scavenge ROS in senescent cells by directly binding to the pocket of Keap1 to promote the dissociation and activation of Nrf2. This study showed that SKN-1/Nrf2 signaling was vital to delaying ageing and enhancing anti-stress capacity with vitexin and isovitexin. The findings provide new insights into apigenin C-glycosides activating the SKN-1/Nrf2 pathway and demonstrate their potential as candidates for innovative strategies in chemoprophylaxis against ageing and oxidative-related diseases.

  • 相关文献

[1]Vitexin and isovitexin delayed ageing and enhanced stress-resistance through the activation of the SKN-1/Nrf2 signaling pathway. Tao, Mingfang,Li, Rong,Xu, Tingting,Zhang, Zhuo,Wu, Ting,Pan, Siyi,Xu, Xiaoyun,Tao, Mingfang,Zheng, Dan,Xia, Zhenzhen,Li, Rong,Xu, Xiaoyun. 2023

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：湖北省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台