Chicken muscle antibody array reveals the regulations of LDHA on myoblast differentiation through energy metabolism
文献类型: 外文期刊
作者: Zhang, Zihao 1 ; Luo, Wen 1 ; Chen, Genghua 1 ; Chen, Jiahui 1 ; Lin, Shudai 7 ; Ren, Tuanhui 1 ; Lin, Zetong 1 ; Zhao, Changbin 1 ; Wen, Huaqiang 1 ; Nie, Qinghua 1 ; Meng, Xun 8 ; Zhang, Xiquan 1 ;
作者机构: 1.South China Agr Univ, Coll Anim Sci, Dept Anim Genet Breeding & Reprod, Guangzhou 510642, Peoples R China
2.South China Agr Univ, Guangdong Prov Key Lab Agroanim Genom & Mol Breedi, Minist Agr & Rural Affair, Guangzhou 510642, Peoples R China
3.South China Agr Univ, Key Lab Chicken Genet Breeding & Reprod, Minist Agr & Rural Affair, Guangzhou 510642, Peoples R China
4.South China Agr Univ, State Key Lab Livestock & Poultry Breeding, Guangzhou 510642, Peoples R China
5.South China Agr Univ, Lingnan Guangdong Lab Agr, Guangzhou 510642, Peoples R China
6.Chinese Univ Hong Kong, Dept Orthaeped & Traumatol, Hong Kong 999077, Peoples R China
7.Guangdong Ocean Univ, Coll Coastal Agr Sci, Zhanjiang 524088, Peoples R China
8.Northwest Univ, Sch Life Sci, Xian 710069, Peoples R China
9.Abmart, 333 Guiping Rd, Shanghai 200033, Peoples R China
关键词: Muscle antibody array; Myoblast differentiation; Energy metabolism regulation
期刊名称:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES ( 影响因子:8.2; 五年影响因子:7.8 )
ISSN: 0141-8130
年卷期: 2024 年 254 卷
页码:
收录情况: SCI
摘要: Myoblast proliferation and differentiation are highly dynamic and regulated processes in skeletal muscle development. Given that proteins serve as the executors for the majority of biological processes, exploring key regulatory factors and mechanisms at the protein level offers substantial opportunities for understanding the skeletal muscle development. In this study, a total of 607 differentially expressed proteins between proliferation and differentiation in myoblasts were screened out using our chicken muscle antibody array. Biological function analysis revealed the importance of energy production processes and compound metabolic processes in myogenesis. Our antibody array specifically identified an upregulation of LDHA during differentiation, which was associated with the energy metabolism. Subsequent investigation demonstrated that LDHA promoted the glycolysis and TCA cycle, thereby enhancing myoblasts differentiation. Mechanistically, LDHA promotes the glycolysis and TCA cycle but inhibits the ETC oxidative phosphorylation through enhancing the NADH cycle, providing the intermediate metabolites that improve the myoblasts differentiation. Additionally, increased glycolytic ATP by LDHA induces Akt phosphorylation and activate the PI3K-Akt pathway, which might also contribute to the promotion of myoblasts differentiation. Our studies not only present a powerful tool for exploring myogenic regulatory factors in chicken muscle, but also identify a novel role for LDHA in modulating myoblast differentiation through its regulation of cellular NAD+ levels and subsequent downstream effects on mitochondrial function.
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