Response of the critically endangered Przewalski's gazelle (Procapra przewalskii) to selenium deprived environment
文献类型: 外文期刊
作者: Shen, Xiaoyun 1 ; Huo, Bin 1 ; Li, Yuanfeng 1 ; Song, Chunjie 1 ; Wu, Ting 1 ; He, Jian 1 ;
作者机构: 1.Southwest Univ Sci & Technol, Sch Life Sci & Engn, 59 Middle Sect Qinglong Ave, Mianyang 621010, Sichuan, Peoples R China
2.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi 832000, Xinjiang, Peoples R China
3.Southwest China, World Bank Poverty Alleviat Project Off Guizhou, Guiyang 550004, Peoples R China
关键词: P; przewalskii; Omics techniques; Selenium-deprived environment; Response mechanism; The Qinghai-Tibetan Plateau
期刊名称:JOURNAL OF PROTEOMICS ( 影响因子:4.044; 五年影响因子:4.02 )
ISSN: 1874-3919
年卷期: 2021 年 241 卷
页码:
收录情况: SCI
摘要: Selenium (Se) is an essential mineral nutrient for animals. Se deprivation can lead to many disorders and even death. This study investigated the response of Przewalski's gazelle (P. przewalskii) to Se-deprived environment. We found that Se deprivation in soil and forage not only influenced the mineral contents of the blood and hair in P. przewalskii, but also severely disrupted their blood parameters. We identified significant changes in the abundance of 146 proteins and 25 metabolites (P < 0.05) in serum, including the selenoproteins L8IG93 (glutathione peroxidase) and F4YD09 (Cu/Zn superoxide dismutase). Furthermore, the major known proteins and metabolites associated with the Se stress response in P. przewalskii were Cu/Zn superoxide dismutase, the vitamin K-dependent protein C, the C4b-binding protein alpha chain, complement component C7, lipase linoleic acid, peptidase D, thymidine, pseudo-uridine, L-phenylalanine, L-glutamine, PGA1, and 15-deoxy-delta-12,14PGJ2. The main signaling pathways involved included complement and coagulation cascades, metabolic pathways, and stress granule formation. Our results indicate that the intake of Se-deficient forage elicited an oxidative stress response in P. przewalskii. These findings provide insights into the response mechanisms of this threatened gazelle to Se stress, and enable the development of conservation strategies to protect populations on the QinghaiTibetan Plateau. Significance: This study is the first to point out the presence of oxidative stress in P. przewalskii in seleniumdeficient areas through proteomics and metabolomics studies. These findings should prove helpful for conservation efforts aimed at P. przewalskii populations and maintenance of the integrity of their ecological environment.
- 相关文献
作者其他论文 更多>>
-
Decreasing Toxicity of Heavy Metal to the Altai Sheep by Fertilized Nano-Potassium Molybdate
作者:Zhang, Yunzhuo;Shen, Xiaoyun;Zhou, Ping;Shen, Xiaoyun
关键词:Altai sheep; heavy metal pollution; natural pasture; Nano-K2MoO4; toxicity of heavy metal
-
Effects of Cadmium on Liver Function and Its Metabolomics Profile in the Guizhou Black Goat
作者:Li, Yuanfeng;Shen, Xiaoyun;Shen, Xiaoyun
关键词:metabolomics; cadmium; goat; liver
-
Cadmium Exposure Affects Serum Metabolites and Proteins in the Male Guizhou Black Goat
作者:Li, Yuanfeng;Shen, Xiaoyun;Shen, Xiaoyun
关键词:metabolomics; proteomics; heavy metal; heavy metal exposure; antioxidant capacity; goat meat
-
Abnormal Phenylalanine Metabolism of Procapra przewalskii in Chronic Selenosis in Selenium-Enriched Habitats
作者:Ren, Hong;Zhou, Ping;Shen, Xiaoyun;Shen, Xiaoyun;Shen, Xiaoyun
关键词:P. przewalskii; phenylalanine; chronic selenosis; proteomics; metabolomics; biochemical analysis
-
Study on the Therapeutic Effect of Modified Yujin Powder on E. coli in the Procapra przewalskii
作者:Song, Chunjie;Shen, Xiaoyun;Gan, Shangquan;Shen, Xiaoyun
关键词:The E; coli; The P; przewalskii; Modified Yujin powder; Gentamicin sulfate; Blood parameter
-
Studies of High Molybdenum-Induced Copper Deprivation in P. przewalskii on the Qinghai Lake Pasture in China
作者:Zhai, Bowen;Zhao, Kui;Liu, Fuyuan;Shen, Xiaoyun;Shen, Xiaoyun
关键词:pasture management; copper deprivation; P; przewalskii; molybdenum; the Qinghai Lake watershed
-
The combinations of sulfur and molybdenum fertilizations improved antioxidant capacity of grazing Guizhou semi-fine wool sheep under copper and cadmium stress
作者:Li, Yuanfeng;Wang, Yachao;Shen, Xiaoyun;Shen, Xiaoyun;Shen, Xiaoyun;Li, Yuanfeng;Liu, Fuyuan
关键词:Guizhou semi-fine wool sheep; Copper and cadmium pollution; Sulfur and molybdenum fertilization; Antioxidant capacity