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Effect of composting on the conjugative transmission of sulfonamide resistance and sulfonamide-resistant bacterial population

文献类型： 外文期刊

作者： Lin, Hui 1 ; Sun, Wanchun 1 ; Jin, Danfeng 3 ; Yu, Qiaogang 1 ; Yang, Yuyi 4 ; Zhang, Zulin 2 ; Sun, Pengfei 5 ; Ma, Junw 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Environm Resource Soil & Fertilizers, Hangzhou 310021, Peoples R China

2.James Hutton Inst, Aberdeen AB15 8QH, Scotland

3.Jiangxi Acad Sci, Inst Microbiol, Nanchang 330096, Jiangxi, Peoples R China

4.Chinese Acad Sci, Wuhan Bot Garden, Key Lab Aquat Bot & Watershed Ecol, Wuhan 430074, Peoples R China

5.Chinese Acad Sci, State Key Lab Soil & Sustainable Agr, Zigui Ecol Stn Three Gorges Dam Project, Nanjing 210008, Peoples R China

关键词： Antibiotic resistance gene; Bacterial conjugation; Bacterial pathogen; Horizontal gene transfer; Bacillus anthracis

期刊名称：JOURNAL OF CLEANER PRODUCTION （ 影响因子：9.297； 五年影响因子：9.444 ）

ISSN： 0959-6526

年卷期： 2021 年 285 卷

页码：

收录情况： SCI

摘要： The effect of composting practice on reducing the health risk of manure-derived antibiotic resistance is mainly assessed based on the abundance of antibiotic resistance determinants. This study evaluated the impact of industrial thermophilic manure composting in controlling the risk of sulfonamide resistance (SR) by identifying the patterns of horizontal gene transfer events via conjugation experiments and analyzing the community distribution of sulfonamide-selectively cultured bacteria (SRB) via 16S rRNA sequencing. Results showed that composting removed 75.9% of sulfonamide residues and inhibited the transfer of SR from manure to an Escherichia coli recipient, with variation according to the resistance gene. Composting decreased the abundances and conjugative transfer of sul2 and intI1 effectively but not that of sul1, which is essential for E. coli SR acquisition, and it was more effective in suppressing the co transfer of sul1 with sul2/intI1 rather than the transfer of sul1 individually. Besides, it was found that SRB community responded more effectively to composting when compared with the total bacterial community. The SRB in raw compost showed a predominance of Proteobacteria, whereas the SRB in mature compost mirrored the total bacteria community. Bacillus anthracis, a major sulfonamide-resistant pathogen, was enriched after composting. Overall, composting failed to reduce the risks of sul1 and sulfonamide-resistant pathogenic bacteria effectively, which should be essential targets to optimize manure composting for decreasing the dissemination of antibiotic resistance. (C) 2020 Elsevier Ltd. All rights reserved.

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