Commercial vaccines used in China do not protect against a novel infectious bursal disease virus variant isolated in Fujian
文献类型: 外文期刊
作者: Hou, Bo 1 ; Wang, Chen-Yan 1 ; Luo, Zhong-Bao 2 ; Shao, Guo-Qing 1 ;
作者机构: 1.Fujian Acad Agr Sci, Fujian Anim Dis Control Technol Dev Ctr, Inst Anim Husb & Vet Med, Fuzhou, Fujian, Peoples R China
2.Fujian Sunner Dev Co, Nanping, Fujian, Peoples R China
3.Jiangsu Acad Agr Sci, Natl Res Ctr Engn & Technol Vet Bioprod, Inst Vet Med, Nanjing, Jiangsu, Peoples R China
关键词: commercial vaccines; infectious bursal disease virus; novel variant; vaccine efficacy
期刊名称:VETERINARY RECORD ( 影响因子:2.56; 五年影响因子:3.069 )
ISSN: 0042-4900
年卷期: 2022 年 191 卷 10 期
页码:
收录情况: SCI
摘要: Background Since 2018, atrophy of the bursa has been found among vaccinated chickens with high antibody titres against infectious bursal disease virus (IBDV) in Fujian, China, suggesting poor vaccine efficacy against circulating IBDV strains. Methods Novel IBDV strains were isolated, and vp2 and vp1 genes were sequenced and used to carry out phylogenetic analysis. Pathogenicity was investigated using 21-day-old specific pathogen-free (SPF) chickens. In addition, the effectiveness of current commercial vaccines used in China was evaluated against the isolated novel IBDV strains. Results Six IBDV isolates were successfully obtained, which formed an independent cluster and belonged to genotype A2dB1, based on phylogenetic analysis of the vp2 and vp1 genes. The pathogenicity of the novel IBDV FJ2019-01 isolate in 21-day-old SPF chickens was characterised by severe atrophy of the bursa and a largely decreased number of lymphocytes, atrophy of the follicle and broadening of mesenchyme in the bursa 3-23 days after infection. Unfortunately, all vaccinated chickens with high antibody titres against IBDV also developed atrophy and largely decreased lymphocytes in the bursa, as in the unvaccinated birds challenged with FJ2019-01. Furthermore, high viral loads of FJ2019-01 were detected in the bursa of all vaccinated chickens. Conclusions These findings suggest that current commercial IBDV vaccines used in China did not provide protection against novel IBDV variants.
- 相关文献
作者其他论文 更多>>
-
Effects of Toxin-Antitoxin System HicAB on Biofilm Formation by Extraintestinal Pathogenic E. coli
作者:Hou, Bo;Wang, Chen-Yan;Zhou, Lun-Jiang;Che, Yong-Liang;Chen, Qiu-Yong;Li, Shao-Wen
关键词:
-
Development of a One-Step Real-Time TaqMan Reverse Transcription Polymerase Chain Reaction (RT-PCR) Assay for the Detection of the Novel Variant Infectious Bursal Disease Virus (nVarIBDV) Circulating in China
作者:Wang, Chenyan;Hou, Bo;Shao, Guoqing;Wan, Chunhe;Shao, Guoqing
关键词:infectious bursal disease virus; one-step RT-PCR; real-time TaqMan; nVarIBDV
-
A pathogenic and recombinant infectious bronchitis virus variant (CK/CH/GX/202109) with multiorgan tropism
作者:Wang, Chenyan;Hou, Bo
关键词:Infectious bronchitis virus; proventriculus; recombination; tissue tropism
-
Pathological and Molecular Characterization of a Duck Plague Outbreak in Southern China in 2021
作者:Liang, Zhipeng;Guo, Jinyue;Yuan, Sheng;Cheng, Qing;Zhang, Xinyu;Liu, Zhun;Wang, Congying;Li, Zhili;Huang, Shujian;Wen, Feng;Hou, Bo;Wen, Feng
关键词:duck plague; duck plague virus; Herpesviridae; UL2; LORF11
-
Genetic and pathogenic characteristics of a novel infectious bronchitis virus strain in genogroup VI (CK/CH/FJ/202005)
作者:Wang, Chen-yan;Shao, Guo-qing;Hou, Bo;Luo, Zhong-bao;Shao, Guo-qing
关键词:Infectious bronchitis virus; Pathogenicity; GVI; TC07-2 strain
-
The Immune Efficacy of Inactivated Pseudorabies Vaccine Prepared from FJ-2012 Delta gE/gI Strain
作者:Chen, Qiu-Yong;Wu, Xue-Min;Che, Yong-Liang;Chen, Ru-Jing;Hou, Bo;Wang, Chen-Yan;Wang, Long-Bai;Zhou, Lun-Jiang;Chen, Qiu-Yong;Wu, Xue-Min;Che, Yong-Liang;Chen, Ru-Jing;Hou, Bo;Wang, Chen-Yan;Wang, Long-Bai;Zhou, Lun-Jiang
关键词:pseudorabies virus; inactivated vaccine; vaccine efficacy; control
-
Study on the Antibody Level Differences of PED IgG and IgA, TGE IgG and PoR IgG After Immunization with Different Porcine Viral Diarrhea Vaccine Combinations
作者:Chen, Qiu-yong;Chen, Ru-jing;Wu, Xue-min;Che, Yong-liang;Hou, Bo;Wang, Chen-yan;Wang, Long-bai;Zhou, Lun-jiang
关键词:Antibody level differences; Porcine epidemic diarrhea IgG and IgA; Porcine transmissible gastroenteritis IgG; Porcine rotavirus IgG; Vaccine combination; ELISA detection