Survey and Molecular Characterization of Echinococcus granulosus sensu stricto from Livestock and Humans in the Altai Region of Xinjiang, China
文献类型： 外文期刊
作者： Guo, Baoping 1 ; Zhao, Li 2 ; Zhao, Lu 3 ; Mi, Rongsheng 4 ; Zhang, Xu 2 ; Wang, Bingjie 2 ; Guo, Gang 1 ; Ren, Yuan 1 ; Qi, Wenjing 1 ; Zhang, Zhuangzhi 2 ;
作者机构： 1.Xinjiang Med Univ, Affiliated Hosp 1, State Key Lab Pathogenesis Prevent & Treatment Hig, 137 Liyushan Rd, Urumqi 830054, Peoples R China
2.Xinjiang Acad Anim Sci, Vet Res Inst, 726 Dongrong St, Urumqi 830013, Peoples R China
3.Shaanxi Normal Univ, Coll Life Sci, 620 Xi Changan Ave, Xian 710119, Peoples R China
4.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Key Lab Anim Parasitol, Minist Agr,Lab Qual & Safety Risk Assessment Anim, Shanghai 200241, Peoples R China
关键词： Echinococcus granulosus sensu stricto; prevalence; genetic diversity; cox1; Altai
期刊名称：PATHOGENS （ 影响因子：3.7； 五年影响因子：3.7 ）
ISSN：
年卷期： 2023 年 12 卷 1 期
页码：
收录情况： SCI
摘要： Cystic echinococcosis (CE), caused by the metacestode Echinococcus granulosus sensu stricto (s.s.), is an important zoonotic parasite, endemic in the Altai region of China. It is a serious human health risk and causes livestock losses. To evaluate the prevalence, genetic variation, and population structure of CE, 2898 sheep and 703 cattle were examined from October 2019 to mid-February 2020 in the Altai region (Altai, Habahe, Fuhai, and Buerjin). Sheep had an infection rate of 4.52% (131/2898) and cattle had an infection rate of 4.84% (34/703). In total, 180 cyst isolates were obtained, including 131 sheep, 34 cattle, and 15 from CE human patients. The cysts were investigated using mitochondrial cytochrome C oxidase subunit 1 (cox1). Polymerase Chain Reaction (PCR) results showed that, among the two genotypes of E. granulosus s.s., there were 22 different haplotypes (Haps). Phylogenetic analysis and parsimony network indicated that seventeen (77.27%) Haps belonged to the sheep strain (G1 genotype) and five Haps (22.73%) belonged to the buffalo strain (G3 genotype). Hap3 was the most common haplotype (65.00%, 112/180), which belongs to the G1 genotype. Hap18-Hap22 were found in human samples, indicating that sheep and cattle reservoirs of human CE. Molecular diversity indices revealed the high levels of haplotype diversity and relatively low levels of nucleotide diversity. Tajima's D and Fu's Fs tests displayed that the Altai population had a significant deviation from neutrality. Based on pairwise fixation index (Fst) values, a low level of genetic differentiation was found between the populations of E. granulosus s.s. isolated from different regions. The present survey findings represent an epidemiological survey of CE in the Altai region where there were two genotypes simultaneously and will provide more information on the genetic structure of E. granulosus s.s. within this region.
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