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Essential oils of Zingiber officinale: Chemical composition, in vivo alleviation effects on TPA induced ear swelling in mice and in vitro bioactivities

文献类型： 外文期刊

作者： Zhang, Silu 1 ; Zhang, Lijun 1 ; Yu, Mengjie 1 ; Luo, Donghui 4 ; Chen, Shuai 1 ; Liu, Weifeng 1 ; Zhang, Yehui 1 ; Zhang, Lanyue 4 ; Zhao, Tiantian 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Sericulture & Agrifood Res Inst, Guangdong Key Lab Agr Prod Proc, Key Lab Funct Foods,Minist Agr & Rural Affairs, Guangzhou, Peoples R China

2.Shenzhen Precis Hlth Food Technol Co Ltd, Shenzhen, Peoples R China

3.Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, Guangzhou, Peoples R China

4.Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangdong Prov Key Lab Plant Resources Biorefinery, Guangzhou, Peoples R China

5.Chem & Chem Engn Guangdong Lab, Food Sci & Engn Dept, Chaozhou Branch, Chaozhou, Peoples R China

关键词： Zingiber officinale; edible spices; essential oil; anti-inflammation; anti-bacterial effects; antioxidation; anti-tumor property

期刊名称：FRONTIERS IN NUTRITION （ 影响因子：6.59； 五年影响因子：6.873 ）

ISSN： 2296-861X

年卷期： 2022 年 9 卷

页码：

收录情况： SCI

摘要： Zingiber officinale (ZO) is a traditional food condiment. The essential oils of Z. officinale (ZOEOs) are known to have multiple bioactivities. In this study, gas chromatography mass spectrometer (GC-MS) analytical method was used to identify active ingredient present in ZOEOs. A total of 41 compounds were identified in ZOEOs. Major components in ZOEOs were zingiberene (19.71%), (+)-beta-cedrene (12.85%), farnesene (12.17%), alpha-curcumene (10.18%) and beta-elemene (3.54%). Experimental results of 12-O-tetradecanoylphorbol-13 acetate (TPA) induced ear swelling validation mice model showed that ZOEOs treatment has better anti-inflammatory effect compared with ibuprofen (positive control) at high concentrations. Histological and immunohistochemical analysis showed that ZOEOs significantly decreased COX-2, IL-6 and NF-kappa B expression in a dose dependent manner. The mRNA levels of COX-2 and NF-kappa B were also down regulated by the application of ZOEOs. This indicated that ZOEOs exhibited positive effects in ear skin protection. Antibacterial experimental results showed that EOZOs had anti-bacterial effects on Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. DPPH radical scavenging, A549 cell line and LNCaP cell line inhibition results indicated that ZOEOs exhibited potential antioxidant and anti-tumor properties. The findings of these study provide scientific basis on therapeutic use of ZO in food, cosmetic and pharmaceutical industries.

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