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The relationship between MFN1 copy number variation and growth traits of beef cattle

文献类型： 外文期刊

作者： Yao, Zhi 1 ; Li, Jiaxiao 1 ; Zhang, Zijing 2 ; Chai, Yanan 1 ; Liu, Xian 3 ; Li, Jungang 4 ; Huang, Yajun 4 ; Li, Lijuan 4 ; Huang, Weihong 4 ; Yang, Guojie 4 ; Chen, Fuying 1 ; Shi, Qiaoting 1 ; Ru, Baorui 3 ; Lei, Chuzhao 1 ; Wang, Eryao 2 ; Huang, Yongzhen 1 ;

作者机构： 1.Northwest A&F Univ, Coll Anim Sci & Technol, 22 Xinong Rd, Yangling 712100, Shaanxi, Peoples R China

2.Henan Acad Agr Sci, Inst Anim Husb & Vet Sci, Zhengzhou 450002, Henan, Peoples R China

3.Henan Prov Anim Husb Gen Stn, Zhengzhou 450008, Henan, Peoples R China

4.Jiaxian Anim Husb Bur, Jiaxian 467100, Henan, Peoples R China

关键词： MFN1; Mitochondria; CNV; Cattle; Growth traits; Association analysis

期刊名称：GENE （ 影响因子：3.913； 五年影响因子：3.48 ）

ISSN： 0378-1119

年卷期： 2022 年 811 卷

页码：

收录情况： SCI

摘要： Copy number variation, as a kind of genetic submicroscopic structural variation, refers to the deletion or repetition of a large segment of genomic DNA, involving a segment size ranging from 50 bp to several MB. Mitochondrial fusion protein (MFN1) gene regulates the fusion of mitochondrial outer membrane in cells and maintains the dynamic needs of reticular mitochondria in cells. In this study, we conducted to tested the dstribution characteristics of MFN1-CNV in 522 cattles across Xianan cattle (XN), Pinan cattle (PN), Qinchuan cattle (QC), Jiaxian cattle (JX), Yunling cattle (YL), and correlated it with phenotypic traits. Then we observed the expression of MFN1 in various tissues of QC cattle (n = 3), and the expression levels were higher in lung and muscle. The results showed that there was significant correlation between MFN1 gene CNV and hucklebone width of QC cattle, hip width and height at sacrum of JX red cattle, chest width and rump length of YL cattle (P < 0.05). Individuals with duplication type were better than the type of normal or deletion in phenotypic traits. In conclusion, our data showed the correlation between MFN1 gene and growth traits of Chinese cattle. MFN1 gene can be used as a molecular marker for cattle selection and breeding, and accelerate the improvement of Chinese cattle.

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