Identification of genes related to resistance against S. Typhimurium in ovine macrophages
文献类型: 外文期刊
作者: Wang, Mengyao 1 ; Yang, Dongbing 1 ; Liu, Zhexi 1 ; Wei, Shao 1 ; Wang, Linli 1 ; Ai, Yue 1 ; Zhang, Xiaosheng 4 ; Han, H 1 ;
作者机构: 1.China Agr Univ, Coll Anim Sci & Technol, Beijing Key Lab Anim Genet Improvement, Beijing, Peoples R China
2.China Agr Univ, Coll Anim Sci & Technol, Natl Engn Lab Anim Breeding, Beijing, Peoples R China
3.China Agr Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod, Minist Agr & Rural Affairs, Beijing, Peoples R China
4.Tianjin Acad Agr Sci, Inst Anim Sci & Vet Med, Tianjin, Peoples R China
关键词: Sheep; Macrophage; S. Typhimurium; RNA-seq
期刊名称:MICROBIAL PATHOGENESIS ( 影响因子:3.738; 五年影响因子:3.663 )
ISSN: 0882-4010
年卷期: 2020 年 139 卷
页码:
收录情况: SCI
摘要: Salmonella enteric serovar Typhimurium (S. Typhimurium) is a zoonotic pathogen causing public health hazards. Identification of genes related to macrophages resistance to S. Typhimurium and their immune mechanisms can provide a theoretical basis for disease resistance. In this study, sixty significant differentially expressed genes were screened between susceptible and resistant sheep macrophages by transcriptome RNA-seq. Eight significantly enriched GO terms and six canonical pathways were involved by GO and KEGG enrichment analysis. Furthermore, knockdown of HMOX1 and SLPI increased remarkably the clearance of S. typhimurium, but SPP1 had little effect on the clearance of S. Typhimurium within sheep macrophages. Altogether, these results suggest that many genes of macrophages were reprogrammed via S. Typhimurium infection, some of which may facilitate host defence against Salmonella, while others allow Salmonella to escape.
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