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Polymorphism and expression level of the FADS3 gene and associated with the growth traits in Hu sheep

文献类型： 外文期刊

作者： Zeng, Xiwen 1 ; Wang, Weimin 1 ; Zhang, Deyin 2 ; Li, Xiaolong 1 ; Zhang, Yukun 2 ; Zhao, Yuan 2 ; Zhao, Liming 1 ; Wang, Jianghui 1 ; Xu, Dan 1 ; Cheng, Jiangbo 1 ; Li, Wenxin 1 ; Zhou, Bubo 1 ; Lin, Changchun 1 ; Yang, Xiaobin 1 ; Zhai, Rui 1 ; Ma, Zongwu 1 ; Liu, Jia 1 ; Cui, Panpan 1 ; Weng, Xiuxiu 2 ; Wu, Weiwei 3 ; Zhang, Xiaoxue 1 ; Zheng, Wenxin 4 ;

作者机构： 1.Gansu Agr Univ, Coll Anim Sci & Technol, Lanzhou, Gansu, Peoples R China

2.Lanzhou Univ, Coll Pastoral Agr Sci & Technol, State Key Lab Grassland Agroecosyst, Lanzhou, Gansu, Peoples R China

3.Xinjiang Acad Anim Sci, Inst Anim Sci, Urumqi, Xinjiang, Peoples R China

4.Xinjiang Acad Anim Sci, Inst Anim Husb Qual Stand, Urumqi, Xinjiang, Peoples R China

5.Xinjiang Acad Anim Sci, Inst Anim Husb Qual Stand, Urumqi 830000, Xinjiang, Peoples R China

关键词： FADS3; qRT-PCR; association analysis; growth traits; Hu sheep

期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：3.7； 五年影响因子：3.3 ）

ISSN： 1049-5398

年卷期： 2023 年

页码：

收录情况： SCI

摘要： Growth traits are the economically important traits of sheep, and screening for genes related to growth and development is helpful for the genetic improvement of ovine growth traits. The fatty acid desaturase 3 (FADS3) is one of the important genes affecting the synthesis and accumulation of polyunsaturated fatty acids in animals. In this study, the expression levels of the FADS3 gene and polymorphism of the FADS3 gene associated with growth traits in Hu sheep were detected using quantitative real-time PCR (qRT-PCR), Sanger sequencing, and KAspar assay. The result showed that the expression levels of the FADS3 gene were widely expressed in all tissues, and the expression level of FADS3 in the lung was significantly higher than in other tissues (p < .05). Then, the polymorphism locus g. 2918 A > C was detected in intron 2 of the FADS3 gene, and associated analysis showed that the mutation in the FADS3 gene was associated significantly with growth traits (including body weight, body height, body length, and chest circumference, p < .05). Therefore, individuals with AA genotype showed significantly better growth traits than those with CC genotype, and FADS3 gene could be a candidate gene for improving growth traits in Hu sheep.

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