Transcriptome and Metabolome Analyses Reveal the Mechanism of Corpus Luteum Cyst Formation in Pigs
文献类型: 外文期刊
作者: Dai, Jiage 1 ; Cai, Jiabao 1 ; Zhang, Taipeng 3 ; Pang, Mingyue 1 ; Xu, Xiaoling 1 ; Bai, Jiahua 1 ; Liu, Yan 1 ; Qin, Yusheng 1 ;
作者机构: 1.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing 100097, Peoples R China
2.China Agr Univ, Coll Anim Sci & Technol, Beijing 100193, Peoples R China
3.Hebei Univ Engn, Coll Life Sci & Food Engn, Handan 056038, Peoples R China
4.Beijing Univ Agr, Anim Sci & Technol Coll, Beijing 102206, Peoples R China
关键词: luteal cyst; choline; Pi3k-Akt; MAPK; ALDH
期刊名称:GENES ( 影响因子:3.5; 五年影响因子:3.9 )
ISSN:
年卷期: 2023 年 14 卷 10 期
页码:
收录情况: SCI
摘要: Corpus luteum cysts are a serious reproductive disorder that affects the reproductive performance of sows. In this study, transcriptome and metabolome datasets of porcine normal and cyst luteal granulosa cells were generated to explore the molecular mechanism of luteal cyst formation. We obtained 28.9 Gb of high-quality transcriptome data from luteum tissue samples and identified 1048 significantly differentially expressed genes between the cyst and normal corpus luteum samples. Most of the differentially expressed genes were involved in cancer and immune signaling pathways. Furthermore, 22,622 information-containing positive and negative ions were obtained through gas chromatography-mass spectrometry, and 1106 metabolites were successfully annotated. Important differentially abundant metabolites and pathways were identified, among which abnormal lipid and choline metabolism were involved in the formation of luteal cysts. The relationships between granulosa cells of luteal cysts and cancer, immune-related signaling pathways, and abnormalities of lipid and choline metabolism were elaborated, providing new entry points for studying the pathogenesis of porcine luteal cysts.
- 相关文献
作者其他论文 更多>>
-
HOG1 Mitogen-Activated Protein Kinase Pathway-Related Autophagy Induced by H2O2 in Lentinula edodes Mycelia
作者:Yan, Dong;Fan, Yangyang;Song, Shuang;Guo, Yuan;Liu, Yu;Gao, Qi;Wang, Shouxian;Xu, Xiaoling;Liu, Fang
关键词:Lentinula edodes; H2O2; autophagy; LeATG8; LeHOG1
-
Rational design, synthesis and binding mechanisms of novel benzyl geranate derivatives as potential eco-friendly aphid repellents
作者:Pan, Shi-Xiang;Yang, Zhao-Kai;Liu, Yan;Shi, Zhuo;Zhou, Zheng-Xin;Yang, Xin-Ling;Qin, Yao-Guo;Qin, Yao-Guo;Qu, Cheng;Luo, Chen;Li, Xue-Sheng;Yang, Xin-Ling
关键词:rational design; eco-friendly aphid-repellent; plant volatile organic compounds; odorant-binding proteins
-
Association of Metabolic and Endocrine Disorders with Bovine Ovarian Follicular Cysts
作者:Xu, Xiaoling;Bai, Jiahua;Liu, Kexiong;Xiao, Linli;Qin, Yusheng;Gao, Meihong;Liu, Yan
关键词:metabolic disorder; RNA sequencing; ovarian steroidogenesis pathway; follicular cysts; bovine
-
Progesterone Induces Apoptosis and Steroidogenesis in Porcine Placental Trophoblasts
作者:Liu, Yueshuai;Cao, Xin;Liu, Yueshuai;Ding, Hongxiang;Liu, Yan;Feng, Tao;Liu, Yueshuai;Ding, Hongxiang;Liu, Yan;Feng, Tao;Liu, Yueshuai;Ding, Hongxiang;Liu, Yan;Feng, Tao;Yang, Yuze
关键词:progesterone; porcine placental trophoblast cell; steroidogenesis; gene expression
-
N-Carbamylglutamate Improves Reproductive Performance and Alters Fecal Microbiota and Serum Metabolites of Primiparous Sows during Gestation after Fixed-Time Artificial Insemination
作者:Feng, Tao;Xiao, Linli;Bai, Jiahua;Ding, Hongxiang;Pang, Liyan;Song, Yuqing;Qin, Yusheng;Xu, Xiaoling;Wang, Jing;Liu, Yan;Feng, Tao;Xiao, Linli;Bai, Jiahua;Ding, Hongxiang;Pang, Liyan;Song, Yuqing;Qin, Yusheng;Xu, Xiaoling;Wang, Jing;Liu, Yan;Feng, Tao;Xiao, Linli;Bai, Jiahua;Ding, Hongxiang;Pang, Liyan;Song, Yuqing;Qin, Yusheng;Xu, Xiaoling;Wang, Jing;Liu, Yan
关键词:N-carbamylglutamate; fixed-time artificial insemination; sow reproductive performance; microbial community; metabolic profiles
-
Microorganisms in the reproductive system and probiotic's regulatory effects on reproductive health
作者:Feng, Tao;Liu, Yan;Feng, Tao;Liu, Yan
关键词:Reproduction; Reproductive system; Reproductive microbiome; Probiotic; Regulation effect
-
Effect of Maternal Sildenafil Supplementation During Gestation on the Reproductive Performance of Sows/Gilts and Growth Performance of Neonatal Piglets
作者:Wang, Yue;Zhao, Wei;Yao, Fusheng;Wang, Wenjing;Hu, Xiao;Cheng, Linghua;An, Lei;Tian, Jianhui;Qin, Yusheng
关键词:sildenafil; sows; gilts; litter size; birth weight