文献类型： 外文期刊

作者： Aldamarany, Waleed A. S. ¹ ; Taocui, Huang ³ ; Liling, Deng ⁴ ; Wanfu, Yang ¹ ; Zhong, Geng ¹ ;

作者机构： 1.Southwest Univ, Coll Food Sci, Chongqing 400715, Peoples R China

2.Al Azhar Univ, Fac Agr, Assiut Branch, Food Sci & Technol Dept, Assiut, Egypt

3.Chongqing Acad Agr Sci, Chongqing 400060, Peoples R China

4.Chongqing Med & Pharmaceut Coll, Sci & Technol Dept, Chongqing 401334, Peoples R China

5.Chongqing Key Lab Specialty Food Cobuilt Sichuan &, Chongqing 400715, Peoples R China

关键词： perilla oil; sunflower oil; tea seed oil; anti-obesity effect; inflammation; lipid metabolism

期刊名称：POLISH JOURNAL OF FOOD AND NUTRITION SCIENCES （ 影响因子：2.4； 五年影响因子：2.8 ）

ISSN： 1230-0322

年卷期： 2023 年 73 卷 1 期

页码：

收录情况： SCI

摘要： Obesity has become one of the most prevalent chronic diseases worldwide, which affects people's health and daily lives. Therefore, this study aimed to investigate the anti-obesity effects of perilla seed oil (PSO), sunflower oil (SFO), and tea seed oil (TSO) and their potential mechanisms in mice fed a high-fat diet (HFD). Mice were divided into five groups: ND, mice fed a normal diet; HFD, mice fed a high-fat diet; PSO, SFO, and TSO, mice fed a high-fat diet supplemented with PSO, SFO, and TSO at 2 g/kg body weight per day, respectively. Our findings showed that oral supplementation with all three oils for 8 weeks significantly reduced body weight, tissue weight, insulin resistance index, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and free fatty acids (FFA), and markedly alleviated hyperglycemia, hyperlipidemia, and hepatic steatosis in obese mice. It also decreased leptin, pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, and (IL)-1beta (IL-1 beta), and increased anti-inflammatory adipokine adiponectin at both secretion and mRNA expression levels in the epididymal adipose tissue (EAT). Moreover, PSO, SFO, and TSO administration increased the expression levels of fatty acid beta-oxidation-related genes, including peroxisome proliferator-activated receptor-alpha (PPAR-alpha), carnitine palmitoyltransferase 1a (CPT1a) and CPT1b, and thermogenesis-related genes such as uncoupling protein 1 (UCP1), and decreased the expression levels of lipid synthesis-related genes, including fatty acid synthase (FAS) and PPAR-gamma in EAT. In conclusion, PSO, SFO, and TSO supplementation could have potential anti-obesity effects in HFD-fed mice by reducing inflammation and improving lipid metabolism.